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Berberine can interact with some medications, including statins, anti-tumor medications and pain relievers such as acetaminophen (Tylenol), blood thinners such as warfarin or medicines that cause drowsiness or sedation

Before Datroway was approved, it went through multiple phases of clinical trials to assess how well it worked, what side effects it caused, and whether it was better than existing treatments

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It received FDA approval in 2014 for type 2 diabetes, and in 2020 an additional indication was added to reduce major adverse cardiovascular events in adults with type 2 diabetes

In several studies, supplementation with carnitine was shown to improve constipation challenges