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Unsurprisingly, GLP-1s are growing faster: 17.5% annually versus 11.3% for oncology, but from a much smaller base

In preliminary intervention studies, pharmacologic doses of betaine (1,500 to 6,000 mg/day) were found to reduce blood homocysteine concentrations in a small number of volunteers with normal-to-mildly elevated homocysteine concentrations (37-40)

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The intranasal administration in rats typically requires anesthesia, although devices are being developed to circumvent this limitation