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PMID: 12674428, DOI: 10.1377/hlthaff.22.2.243

The phase of a trial reveals what stage the drug is in to get approval for a specific condition

El dato animal de Tomas 1993 Tomas 1993 (Long-R3-IGF-1) administr Long-R3-IGF-1 subcutneo a ratas en restriccin calrica y report: Aumento significativo de ganancia de peso vs ratas controles a dieta similar Retencin de nitrgeno indicando preservacin de masa magra Eficacia mayor que IGF-1 nativo a dosis equimolar (consistente con la potencia in vitro 3) El hallazgo es mecansticamente coherente : ms IGF-1 libre ms seal en IGF-1R ms anabolismo en msculo y otros tejidos receptivos

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Trials record what they pre-specify and what participants report, so they can miss symptoms that were not actively measured

For short-term management of Mounjaro-related nausea, antiemetics may be considered with important UK safety restrictions: domperidone has cardiac/QT interval prolongation risks (use lowest dose, shortest duration, avoid in cardiac risk patients) and metoclopramide is limited to maximum 5 days use in adults due to extrapyramidal side effect risks