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Homocysteine is either used to regenerate methionine or is directed to the transsulfuration pathway

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PERK phosphorylates the eukaryotic translation initiator factor 2 (eIF2), which increase the translation of transcription factor-4 (ATF4) and subsequently upregulating the expression of C/EBP homologous protein (CHOP) and tribbles homolog 3 (TRIB3)

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On-target deletion mutations were around the start codon of RSMC

Toleransi dan keamanan glutathione dianggap baik, kecuali pada penelitian dengan glutathione yang disuntikkan