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Cell Sci

The pivotal Phase 2 trial (NCT04881760), published in The New England Journal of Medicine (Jastreboff et al., 2023), enrolled 338 adults with BMI 30 or higher

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The absolute bioavailability following intramuscular injection was found to be approximately 1419% in rats and 4551% in beagle dogs, indicating variable absorption depending on the species and administration route

Treatment recommendations are based on provider evaluation, medical history, current medications, and clinical judgment

Tesofensine is still under investigation and does not yet have FDA approval for any indication