The research demonstrates that vitamin C supplementation helps regenerate glutathione from its oxidized form back to its active state
Dairy Chemistry and Biochemistry
FIGURE 1 3 Current diagnosis of oxidative stress The most common approach to diagnose OS is the static measurement of OS biomarkers, but the effective management of OS relies on assessing oxidative burden accurately and implementing targeted therapies that extend beyond mere ROS scavenging
O.HeS.WangY.JiangM.WangY.OrgahE
What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself