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The rise of dual GLP-1/GIP agonists like tirzepatide signals a pivotal shift in how we approach both diabetes and obesity

At the same time, molecular biology experiments with cell-free translation of islet mRNA indicated that the real proglucagon precursor was much larger than the 69 amino acids that make up glicentin [20], engendering the question: what peptide sequences were encoded in the rest of proglucagon, designated the so called major proglucagon fragment (MPGF)

But as you mentioned, Mike, there are lots of knock-on benefits that we're seeing as well

Cagrilintide vs Semaglutide: Which GLP-1 Peptide Is Better for Weight Loss