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Herein, we review the molecular mechanisms governing iron homeostasis, the roles of iron metabolism disorders and ferroptosis in disease pathogenesis, and the latest breakthroughs in iron-regulated therapeutic agents

Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases Oxidative stress is a potentially damaging imbalance of redox states in the body, involving excessive generation of toxic ROS and/or dysfunction of the protective antioxidant system 22 , 23