However, as Ozempic use rises globally, so are the reports of severe complications from GLP-1s, including gastroparesis and pancreatitis
Tirzepatide 15 mg/week administered to adults with HFpEF, reduced the risk of death from cardiovascular causes or worsening heart failure events resulting in hospitalization, intensification of oral diuresis, or intravenous drugs in urgent care setting by 38% compared to placebo [72]
But dosing alone does not determine outcomes
Like any medication, semaglutide can cause side effects
They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain
Niacinamide is one of two major forms of vitamin B3, the other being niacin (nicotinic acid)