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Reflecting this difficulty Novartis and Probiodrug had to abandon some of their early drug candidates because they proved unsafe and too toxic (Cordes)

A 2025 narrative review published in Frontiers in Clinical Diabetes and Healthcare analyzed the existing body of research on GLP-1 receptor agonists and exercise

Although the significance of this finding requires further investigation, it suggests that GLP-1 RA therapy could help facilitate more adaptive behaviors, especially in individuals struggling with compulsive eating or substance use, by potentially enhancing their capacity for new learning and behavioral flexibility

This innovation is likely to boost adherence, increase prescription rates, and tap into new patient segments in both diabetes and obesity management

Cell Death Dis 9(2):212

Covariates We selected covariates assumed to be associated with selection of patients for GLP-1 RAs, SGLT-2 inhibitors, DPP-4 inhibitors and risk of suicide or suicide attempts from the Danish National Patient Registry and Danish National Prescription Registry