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The tirzepatide weight loss timeline shows progressive results over the first 40 to 72 weeks, with the most rapid loss often occurring in the middle months of treatment as the dose reaches therapeutic levels

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Diabetic wound healing research showed 9-fold increases in collagen synthesis with improved epithelialization

Additional analyses models (ie, models developed in MEDAL and externally validated in LUNA) showed poorer predictive ability for both the internally validated only models (C-statistics ranging from 0.631 to 0.719) (online supplemental table A5) and the models for external validation (C-statistics 0.610 and 0.677) (online supplemental table A5)

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