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Initially, a person may need B12 supplementation shots every day for around two weeks or until symptoms improve

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Injectable medicines should be administered by appropriately trained healthcare professionals in clinical settings with emergency resuscitation facilities available

They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

Some of them affect children (degenerations with early onset, such as Friedreichs ataxia, injuries, and tumors in children)