Why clinicians dislike it: It destroys signal quality
TNF--induced necroptosis causes damage to cerebral endothelial cells in blood vessels, neuroinflammation, and dysregulation of astrocyte Kir4.1 [108, 109]
Recently, Wei et al
It helps reduce oxidative stress, promote tissue repair, and boost recovery after training or daily challenges
Additionally, the role of non-classical ferroptosis regulators (e.g., FSP1, DHODH, and GCH1/BH4) in LN is entirely unexploredwhether these radical-trapping antioxidant pathways compensate for GPX4 deficiency in immune cells or renal tissue, or if their dysfunction exacerbates ferroptosis susceptibility, has not been investigated
B-12 also has an important role in forming new red blood cells and can cause an anemia if deficient