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GPCRs promote the differentiation of regulatory T cells (Tregs) by activating mTOR and inhibiting the histone deacetylase (HDAC) pathway (169)

[DOI] [PubMed] [Google Scholar] 67.De Luca I., di Cristo F., Valentino A., Peluso G., di Salle A., Calarco A

Neither provided information about the randomisation process, complete outcome data and full reporting of results

This reduced inflammation was characterized by decreased airway resistance, eosinophil count, eosinophilia, Th17 cells, and Retinoic acid receptor-related orphan receptor (ROR)t protein and restored IL-6, TNF- and IL-17A levels [137]

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