After 3 h of OGD treatment in HUVECs, WB results showed that the expression of Ki-67 and Lamin B decreased, while the expression of P53, P21, P16, and -H2AX significantly increased (Figure 3A)
No injectable or systemic formulations are FDA-approved for any indication as of February 14, 2026 [11]
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Applications in Research Investigation of FOXO4p53 proteinprotein interactions Study of cellular senescence and transcription factor regulation In vitro models examining stress-response signalling pathways Use as a research tool in aging and cell-cycle biology studies Handling & Stability Handle under dry, clean laboratory conditions Reconstitute in sterile water or appropriate buffered solution Avoid vigorous agitation during dissolution Aliquot reconstituted solutions to avoid repeated freezethaw cycles Store reconstituted material at 20 C or below for long-term stability Specifications Summary Purity: 98 % (HPLC) Appearance: White to off-white lyophilised powder Peptide Type: Synthetic modified research peptide Molecular Weight: 5358.05 g/mol Solubility: Water, buffered aqueous solutions Storage: 20 C, desiccated, protected from light Precautions & Notes Intended strictly for laboratory research use Not for human or veterinary application Experimental outcomes may vary depending on model system and assay design Appropriate controls are recommended to interpret pathway-specific effects References Baar M.P

Endotoxicity This test, performed alongside sterility testing, ensures the medication is free from harmful bacterial toxins
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