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The gradient was programmed as follows: 02 min 35% B, 28 min from 35 to 80% B, 822 min from 80 to 99% B, 2236 min 99% B, and 36.140 min from 99 to 35% B

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2 In Semaglutide, the key amino acid substitutions relative to wild-type human GLP-1 are glycine to 2-aminoisobutyric acid (Aib) replacement at position 8 and attachment of an octadecanoic diacid to the side chain of Lys-26

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