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The drug dosage and number in each group are shown in Table 1

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In addition to the VHL-HIF-VEGF/vascular endothelial growth factor receptor (VEGFR) pathway, VHL mutations affect signaling regulation in the mTOR and epidermal growth factor receptor (EGFR) pathways, promoting tumor growth (130)

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If the symptoms persist for over 3 months (12 weeks) sinusitis is said to be chronic

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