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This may be part of a vicious cycle, where a worsening of autism leads to unusual behaviors including pica, which in turn leads to increased consumption of toxic metals and a worsening of symptoms

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Studies have also indicated that elevated TNF- and dysregulated iron homeostasis often reinforce each other in tumor or inflammation models, collectively driving cell damage and death (120)

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The next decade will be pivotal in translating accumulating clinical and preclinical findings into meaningful therapies that can prevent or reverse the course of DN, ultimately improving outcomes for millions of patients