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Maekawa et al., 2007

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thus, metformin may be used off-label by some clinicians for weight loss if the more preferred agents are not affordable or not appropriate for a specific patient. So for someone who just wants to lose weight, phentermine might be the better choice

However, this doesn't mean compounded medications are unregulated

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Key variants in genes such as GLP1R (rs6923761) and FTO (rs9939609) influence medication tolerance, weight loss trajectory, and the likelihood of gastrointestinal or musculoskeletal responses