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Pathogenesis involves antibody-mediated thyroid tissue damage, progressive fibrosis, and impaired synthesis of triiodothyronine (T3) and thyroxine (T4) (Cayres et al

Formation of -aminoadipic semialdehyde from pipecolic acid is catalyzed by the dehydrogenase encoded by the aldehyde dehydrogenase 7 family member A1 gene (ALDH7A1)

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Research shows it affects DNA repair genes and antioxidant response pathways significantly

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Growth-factor signalling Reported to raise GH-receptor expression and drive fibroblast migration