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How Long Does Semaglutide Fatigue Last Most patients report that semaglutide-related fatigue peaks within the first 1-2 weeks of starting treatment or after each dose increase, then gradually improves over 2-4 weeks

The medication may help preserve lean body mass better than caloric restriction alone, though resistance exercise remains important during weight loss

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More muscle means a higher calorie burn at rest and if you're postmenopausal, strength training is one of the only ways you can increase your basal metabolic rate

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Ideal candidates often have specific health conditions or dietary restrictions that lead to a deficiency