This estimate is derived from comparative pharmacology and peptide absorption literature rather than from direct human studies: What This Means If you take 10 mg orally, approximately 3.8 mg reaches systemic circulation The remaining 6.2 mg is metabolized by stomach acid, proteases, and first-pass liver metabolism before reaching the bloodstream However, this systemic bioavailability may not directly reflect brain bioavailability (the amount reaching the central nervous system) Brain Penetration A critical distinction: systemic bioavailability (what enters the blood) differs from brain bioavailability (what crosses the blood-brain barrier and reaches neural tissue)
Microsc Res Tech (2003) 60:58192
How Quickly Does The Body Excrete Extra B12
21 Procedure: Precisely weigh 0.05 mg of the glutathione sample, place it in a 10 mL beaker, dissolve it with 2% HPO, transfer it to a 100 mL volumetric flask, and dilute to volume with water
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