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The bodyhacking community reports that they are extremely effective

Vitamin B12 (cobalamin) is a vital nutrient that plays a crucial role in maintaining healthy nerves, red blood cell production, DNA synthesis, and even the health and vibrancy of your skin

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Lions mane is reported to have many beneficial characteristics according to cell cultures and animal models such as antibiotic, anticarcinogenic, antidiabetic, kidney and nervous system protective, liver and heart protective, antihypertensive, anti-inflammatory, and more

PMID 8017933

Side effects are rare and typically limited to mild, transient skin irritation or redness at the application site, particularly with higher concentrations