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Part of the reason comes down to whos taking these medications in the first place

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[11] Pharmaceutical GLP-1 receptor agonists like semaglutide are engineered to resist DPP-4 degradation, providing sustained therapeutic effects

The agency noted 32 adverse event reports between 2019 and 2024including erectile dysfunction, depression, and suicidal ideationand emphasized that topical application does not eliminate systemic absorption

Results typically last a few days before reapplication is required