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Additional risks include diabetic retinopathy complications (particularly with semaglutide in patients with pre-existing retinopathy), acute kidney injury (especially with volume depletion from gastrointestinal effects), and rare cases of intestinal obstruction or ileus
Murrow And The Broadcasts That Riveted A Nation. History of American Journalism, December 31, 2007
HamadaYGotoMNishimuraGNagasakiHSeinoYKamiyaHet al
In the current study, we hypothesized that the loss of responsiveness to GLP-1 contributes to NAFLD disease progression and the beneficial effect of NaB on NAFLD is partially due to its improvement of hepatic GLP-1 sensitivity
Wegovy (semaglutide) targets just one gut hormone, GLP-1
The central reasons (repeatable pattern across literature): Comparator sensitivity: DPP-4i vs sulfonylureas vs SGLT2i changes results Ascertainment differences: Who gets ultrasounds, when, and why Outcome definition: "Thyroid cancer," "tumors," "neoplasm," and "MTC" aren't interchangeable Short follow-up: Better at capturing diagnostic workups than long-term carcinogenesis Residual confounding: Obesity, diabetes duration, smoking, iodine status, healthcare access When Studies Disagree: It's often because they used different comparison drugs, definitions, and populations watched more closely
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