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Crohns Colitis 17 , 14571470 (2023)

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314 In patients with IBS-C, linaclotide was shown to significantly improve IBS-C including symptoms of abdominal pain, complete and spontaneous bowel movements, bloating, straining, and stool consistency

Why: Isotretinoin is derived from vitamin A and combining the two increases the risk of hypervitaminosis A , which can cause: Headaches / pseudotumour cerebri Liver toxicity Nausea Bone pain Skin peeling Mood changes Avoid: Vitamin A capsules Multivitamins containing high-dose retinol Cod liver oil (contains vitamin A) Most multivitamins have Vitamin A with very low levels ( 5,000 mcg

This doesnt just enlarge existing fibers but can also create new ones, leading to real hypertrophy