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Use during pregnancy or breastfeeding only if recommended by your doctor after assessing the potential benefits and risks

This damage can alter the permeability and fluidity of cell membranes, ultimately leading to changes in cellular structure and function, and may trigger cell death [57, 58]

(2007) examined the generation and distribution of protein oxidation adducts with acetaldehyde and lipid peroxidation products: MDA and hydroxynonenal (HNE), as well as ethanol-stimulated expression of CYP2E1 in the oral mucosa of the alcohol-dependent patients diagnosed with leukoplakia (pre-cancerous condition) and squamous cell carcinoma (SCC)

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The bottom line Sleep disruption during perimenopause is real, it's common, and it has clear hormonal and physiological causes

The evidence is sound, and the available human data is real