glutide glp 1 Lesson: Oral Semaglutide: A New GLP-1 Receptor Agonist Product for the Treatment of Type 2 Diabetes Semaglutide GLP-1 Treatment Specialist |

Response can vary

Since brain GLP-1R signaling is to a large extent directly triggered by its peripheral secretion from the intestines via vagal stimulation of the NTS neurons, it seems plausible that proper balance in gut microbiota abundance and diversity can influence action of this peptide in the central nervous system

For someone on a GLP-1 medication where transit time is already extended, this can make the difference between a comfortable daily bowel movement and going 3-4 days without one

She adds that some long-term clinical trials have also demonstrated that a high protein diet can help protect against weight gain after weight loss, and with no real adverse effects on bone density or kidney function

10.1046/j.0007-1331.2001.00757.x 160

Semaglutide should be discontinued at least 2 months before a planned pregnancy due to its long half-life