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Beneficial effects of IGF-I treatment in ALS have been demonstrated both in vivo and in vitro , from which IGF-I has been postulated as an important factor for the maintenance and survival of motor neurons in the spinal cord by activating clue pathways as PI3K/Akt and p44/42 MAPK[333] and ameliorating the superoxide effect[334]

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This GSH-responsive behavior not only caused contrast-enhanced magnetic resonance imaging, but also contributed to the tumor site-specific release of loaded therapeutic agents for realizing selective cancer therapy (Wu et al., 2022)

Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer

There's typically 1-3 days of rest after each injection -- the treatment site may be sore as the inflammatory cascade activates