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2007 Sep 28;361(3):670-4

A Phase 1 clinical trial was initiated in 2012 by Arrowhead Research Corporation

Principles and clinical implications of the brain-gut-enteric microbiota axis

Roman P, Carrillo-Trabaln F, Snchez-Labraca N, Caadas F, Estvez AF, Cardona D

(2016) 10:OC169

Practical timing examples: If you sleep at 10 PM, finish your last meal by 6-7 PM If you sleep at 11 PM, finish your last meal by 7-8 PM If you sleep at midnight, finish your last meal by 8-9 PM After your last meal, the only acceptable items are water, non-caffeinated herbal tea (chamomile and passionflower are excellent options), or a very small handful of berries if blood sugar maintenance requires it