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These conditions share common characteristics: persistent low-grade inflammation, incomplete previous healing, and tissue function that has adapted to a suboptimal state

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In liver disease, semaglutide received FDA accelerated approval in August 2025 for metabolic dysfunction-associated steatohepatitis in adults with moderate-to-advanced fibrosis

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Geng et al., 2025

Understanding why weight regain happens after discontinuing GLP-1 treatment could be crucial for determining their long-term health impacts and the best way to prescribe them in the future