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[1] In 2024, global spend on anti-obesity medication exceeded $30 billion for the first time, which is over a ten-fold increase since 2020, as reported by IQVIA

For instance, the SUSTAIN 7 and PIONEER 10 trials, which assessed the subcutaneous and oral formulations respectively, did not conduct a systematic analysis of ocular ADEs [18, 20]

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Observational studies have tracked the effects of caloric restriction on lean, healthy individuals, and demonstrated that moderate restriction (2230% decreases in caloric intake from normal levels) improves heart function and reduces markers of inflammation (C-reactive protein, tumor necrosis factor [TNF]), risk factors for cardiovascular disease (LDL cholesterol, triglycerides, blood pressure), and diabetes risk factors (fasting blood glucose, insulin levels)