Soneson, C., Love, M
These risks are theoretical, not documented in human trials, but they are reasons community references include cycle off-periods

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References: Acharya Dahal R et al (2014): Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site
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The PrymaLab product is a separate, research-use-only material