Treatment decisions are individualized and may be combined with lifestyle guidance to support long-term wellness
Semaglutide, liraglutide, dulaglutide, exenatide, albiglutide, and lixisenatide are all medications in the GLP-1 receptor agonist class, which are primarily used to improve blood sugar control in people with type 2 diabetes and, in some cases, to support chronic weight management
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Eur J Cardiovasc Nurs (2006) 5:99101
Effects of alogliptin in chronic kidney disease patients with type 2 diabetes
GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)
