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Because of its high sorbitol (a sugar alcohol) content, pear juice helps to draw water into the stool and soften it, making it easier to pass

5-HT-2a receptors : Based on animal models, 5-HT-2a receptors seem to be involved in the more dangerous symptoms of serotonin syndrome (e.g., hyperthermia and increased muscle tone)

Singh suggested the discrepancy may stem from the latter studys design limitations