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It is noteworthy that VEGF overexpression favors neovascularization accompanied by plasma leakage but Ang-1 overexpression favors enlargement of existing blood vessels without favoring plasma leakage [146]

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The C9orf72 DPRs also interact with mitochondrial proteins, resulting in mitochondrial dysfunction, inflammation, and neurotoxicity (Gendron and Petrucelli, 2018)