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The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-dependent Diabetes Mellitus

Due to differences in mechanisms, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists were not included in the definition of GLP-1 RAs users in this study [35,36,37]

consequently, the bioavailability of the active ingredient is relatively lower, and the onset of action is naturally slower

However, higher doses of oral semaglutide are now approved for weight loss

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