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A substantial volume of data indicates that an elevated HR is independently associated with increased cardiovascular morbidity and mortality in the general population, in subjects with cardiovascular diseases, and those with diabetes [13, 14, 38, 39]

318,319,320 When mitophagy is inhibited, mitochondrial homeostasis is easy to be dysregulated, and inappropriate mitochondrial function and excessive ROS appear

Moreover, hippocampal neurogenesis reduces neuronal damage by replacing lost neurons, which appears to improve depressive-like behavior (Zhang et al., 2008)

Z., Yassin M., Mahajna J., Wasser S

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