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Sarkar R, Bansal S, Garg VK

They interact with neurons to regulate synaptic plasticity, not only by modulating neurotransmitter clearance and ionic balance but also through their own intracellular signaling pathways such as p38 MAPK

Singh S

The accumulation of -Syn in excess also activates the autophagy-lysosomal pathway (Zhang et al., 2018), mutations in -Syn proteins undergo misfolding in transcription-translation to produce toxicity, and defective mitophagy further exacerbates neurotoxicity, leading to neuronal loss or damage (Wang et al., 2018)

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Plasma CoQ10 levels were evaluated in six patients with ACTH-dependent adrenal hyperplasia, 19 with secondary solitary hypoadrenalism, and 19 with concurrent hypothyroidism (multiple pituitary deficits)