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Consistently, DM significantly increased the cardiovascular mortality, all-cause mortality, hospitalization rate and prognosis of patients with HFpEF [30, 36, 37]

We have previously identified that Sita (i.e., an DPP4 inhibitor) therapy significantly suppressed the DPP4 activity in circulation which, in turn, markedly increased circulating and tissue levels of SDF-1 and GLP-1 in setting of organ ischemia in rodent [29-32]

More serious risks include pancreatitis, gallbladder disease, acute kidney injury (particularly with dehydration), hypoglycemia (when combined with insulin or sulfonylureas), and thyroid C-cell tumors in animal studies

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Body Composition Shifts As you lose weight, a portion of that loss is lean mass, muscle, bone density, organ tissue

Insurance coverage can offset this, but coverage for weight loss medications remains inconsistent