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It is defined by the association of excess fat mass and a decrease in muscle mass and/or function, and currently constitutes a recognized clinical entity according to the joint consensus of ESPEN and EASO 8

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10.1172/JCI75836 310 XiongG.StewartR

For example, elevated levels of certain saturated fatty acids could indicate a heightened risk of lipotoxicity, which would guide the appropriate use of fatty acid metabolism modulators (138)