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Loss of the normal hepatocytic architecture, vacuoles, degeneration of hepatocytes with pyknotic nuclei (black square& black arrow), fibrosis and congestion around the portal area (black circle), dilation and congestion of portal vein (blue dotted arrow), congestion in hepatocytes and blood sinusoids (black dotted arrow), bi-nucleated hepatocyte (green dotted arrow) were seen in the photomicrograph of T.S in the liver of Tadalafil-treated rabbits [Fig 2C]

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doi: 10.3390/jcm12186053 138

Additionally, if you're interested in exploring other skincare ingredients with potential benefits, you can learn more about Kojic Acid, a chemical derived from various fungi that is widely used in skincare products due to its skin brightening properties

More serious but less common risks include pancreatitis, gallbladder disease, and in people with type 2 diabetes potential worsening of diabetic retinopathy