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10.1016/j.biopha.2020.110627 2 AbdeenA.SamirA.ElkomyA.AboubakerM.HabottaO

Mice unable to form glutathione will die before birth

Beyond genetic predisposition, epigenetic modifications significantly contribute to disease pathogenesis, including DNA methylation, histone modifications, and microRNA (miRNA) regulation

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In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology