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This reduction in SCFAs may play a crucial role in the ENS changes and gut dysmotility seen in PD

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This has permitted a number of small clinical investigations in academic settings

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Increasing the number of intestinal endocrine L-cells According to the impairment of L-cells development in T2DM, a promising strategy for treating T2DM is to increase the number of L-cells in the intestine, thereby increasing the production of GLP-1