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GLP-1s and Muscle Loss: What the Science Says Concerns about muscle loss have been specifically highlighted with GLP-1 medications, partly due to the significant and sometimes rapid weight loss they can induce

By slowing gastric emptying, these medications help patients feel fuller longer after eating smaller portions

This connection has only been established in animal studies

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There is also some evidence that the medication may contribute to worsening retinopathy, a disease affecting the retina