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According to reports, after 24 hours of treatment with celecoxib, an increase in its concentration can enhance the levels of HO-1 mRNA and protein expression in endothelial cells of humans, and the bilirubin content reaches its highest level after 48 hours of celecoxib treatment

doi:10.1007/s10517-012-1574-2

For example, collagen synthesis requires adequate intake of vitamin C, zinc, and specific amino acids like proline and glycine

Tan J, Wang JJ, Flood V, et al

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For localized musculoskeletal injuries, perilesional intramuscular or intratendinous injections may provide enhanced local effects, though systemic administration alone often suffices