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Monthly prescription volumes reached 1.5 million by February 2024, accounting for 0.41% of all prescriptions dispensed in the United States ^22

[52] In light of the disappointing results of clinical trials involving the administration of so-called direct antioxidants (e.g., vitamins C or E or beta carotene) [37], there is growing interest in strategies based on dietary or pharmacological upregulation of endogenous antioxidant defense genes, including those regulated by the master antioxidant and cell protective transcription factor nuclear factor (erythroid-derived 2)-like-2 (Nrf2), which regulates hundreds of antioxidant and cytoprotective proteins [20] by binding at antioxidant response element (ARE) consensus sequences in the promoter region of those genes

In: Jameson JL, DeGroot LJ, eds

The safety profile is extremely well characterized

Current guidelines recommend specific approaches to perioperative management of both GLP-1 receptor agonists and anticoagulants