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Consistent with the cell viability study, the two compounds with side chains on their 10 nitrogen, chlorpromazine and promethazine, exhibited significantly lower potencies against ROS generation with EC50s of 2148 and 9687 nM, respectively (Figure 4C, Table 1)

(2020) 17:e1008347

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GSH has several biological functions including the detoxification of electrophiles, the antioxidant defense, the maintenance of the thiol status of proteins, and the modulation of DNA synthesis and the immune system [4]