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Cys151 residue is required to inhibit Keap1-mediated Nrf2 degradation, thus itaconate upregulates Nrf2 levels via Keap1 alkylation ( Figure 3 )

10.3177/jnsv.47.329 12 HiramatsuA.AikataH.UchikawaS.OhyaK.KodamaK.NishidaY.et al (2019)

They have both been linked to increased melanin production and increased tanning of the skin [2, 3, 4, 5, 6, 7]

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Lindsey Yourman, associate clinical professor in the division of geriatrics, gerontology, and palliative care at the University of California San Diego School of Medicine

Landeta C, McPartland L, Tran NQ, Meehan BM, Zhang Y, Tanweer Z, Wakabayashi S, Rock J, Kim T, Balasubramanian D, Audette R, Toosky M, Pinkham J, Rubin EJ, Lory S, Pier G, Boyd D, Beckwith J (2019) Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes