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Notably, SGLT-2is induce natriuresis and osmotic diuresis, causing a contraction in plasma volume, reduction in blood pressure, and improvement in cardiac preload and afterload [6, 28]

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It has also been demonstrated to have an immunosuppressive effect on the host, as it inhibits the proliferation of T cells resulting in persistent colonization and infection (Schmees et al., 2007)

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